DIRC1

Across TCGA patient cohorts, DIRC1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIRC1-associated genes across cancer lineages are eEF2, ERK2, and FOXO3a_pS318_S321. Each is linked with DIRC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIRC1-to-partner and partner-to-DIRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by DIRC1-low versus DIRC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIRC1→partner) and Y-score (partner→DIRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.514	+3.169	.008	.020	3	1
UCEC	ERK2 →	+0.366	+3.169	<.001	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.147	-3.169	.031	.020	3	1
UCEC	MEK1_p_S217_S221 →	-0.439	-3.000	.003	.036	3	1
UCEC	NF-kB-p65_pS536 →	-0.548	-2.990	.028	.036	3	1
UCEC	Notch1 →	+0.220	+3.169	.004	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eEF2 by DIRC1 expression — UCEC

Explore this box plot interactively →