DIRC1

Across TCGA cell cohorts, DIRC1 RNA expression is significantly associated with the mutation status of many other genes, with 90 significant associations in total. CNS shows the largest number of these associations.

The most reproducible DIRC1-associated genes across cancer lineages are ADAMTS20, ELAPOR2, and EPHB2. Each is linked with DIRC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIRC1-to-partner and partner-to-DIRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAMTS20 grouped by DIRC1-low versus DIRC1-high in KIDNEY.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIRC1→partner) and Y-score (partner→DIRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ADAMTS20 →	+4.954	+0.032	<.001	<.001	3	2
LUNG_NSCLC_LUAD	ELAPOR2 →	+2.887	+0.048	.009	.001	3	2
SKIN	EPHB2 →	+3.082	+0.039	<.001	.003	3	2
LUNG_NSCLC_LUSC	SPATA17 →	+4.108	+0.053	.005	<.001	3	1
LUNG_NSCLC_LUSC	CADPS2 →	+4.108	+0.056	.005	<.001	3	1
PANCREAS	COL12A1 →	+5.614	+0.020	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

ADAMTS20 by DIRC1 expression — KIDNEY

Explore this box plot interactively →