DIRAS2

Across TCGA patient cohorts, DIRAS2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,333 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DIRAS2-associated genes across cancer lineages are SLC5A3, RPS27AP8, and SRP54. Each is linked with DIRAS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIRAS2-to-partner and partner-to-DIRAS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DIRAS2 versus SLC5A3 in CCRCC, with a Pearson correlation of -0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIRAS2→partner) and Y-score (partner→DIRAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLC5A3 →	-1.523	-0.571	<.001	.004	3	2
CCRCC	RPS27AP8 →	-0.810	-0.446	<.001	.006	3	2
CCRCC	SRP54 →	-0.221	-0.503	.009	<.001	3	1
CCRCC	SEC23A →	-0.352	-0.452	.001	.003	3	1
CCRCC	JADE3 →	-0.492	-0.583	.001	.007	3	1
CCRCC	LMBR1 →	-0.430	-0.570	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,333 associations by consensus.

DIRAS2 vs SLC5A3 — CCRCC

Explore this scatter interactively →