DIRAS2

Across TCGA cell cohorts, DIRAS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,231 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible DIRAS2-associated GO terms across cancer lineages are Negative regulation of angiogenesis, Regulation of syncytium formation by plasma membrane fusion, and Extracellular matrix organization. Each is linked with DIRAS2 in more than 5 cancer types. Because this analysis shows association rather than direction, both DIRAS2-to-partner and partner-to-DIRAS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of angiogenesis grouped by DIRAS2-low versus DIRAS2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DIRAS2→partner) and Y-score (partner→DIRAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of angiogenesis →	-0.038	-1.530	.002	.002	3	6
OVARY	Regulation of syncytium formation by plasma membrane fusion →	+0.090	+1.528	.008	.007	3	5
BREAST	Extracellular matrix organization →	-0.102	-0.117	.009	.002	2	5
OVARY	Protein transmembrane transport →	+0.036	+1.329	.008	.004	3	4
OVARY	Regulation of myoblast fusion →	+0.097	+1.573	.004	.006	3	4
OVARY	Regulation of midbrain dopaminergic neuron differentiation →	-1.131	-1.137	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,231 associations by consensus.

Negative regulation of angiogenesis by DIRAS2 expression — LUNG_SCLC

Explore this box plot interactively →