DIRAS1

Across TCGA patient cohorts, DIRAS1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIRAS1-associated genes across cancer lineages are eIF4E, Fibronectin, and FOXO3a_pS318_S321. Each is linked with DIRAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIRAS1-to-partner and partner-to-DIRAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by DIRAS1-low versus DIRAS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIRAS1→partner) and Y-score (partner→DIRAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.207	+2.820	.020	.035	3	1
UCEC	Fibronectin →	-0.303	-3.160	.030	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.138	-1.700	.009	.044	3	1
UCEC	ACC1 →	+0.366	+1.700	.017	.044	3	1
UCEC	JNK2 →	+0.198	+2.834	.019	.034	3	1
UCEC	Ku80 →	+0.253	+2.009	.011	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

eIF4E by DIRAS1 expression — UCEC

Explore this box plot interactively →