DIPK1A

Across TCGA patient cohorts, DIPK1A mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIPK1A-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and A-Raf_pS299. Each is linked with DIPK1A in more than 1 cancer types. Because this analysis shows association rather than direction, both DIPK1A-to-partner and partner-to-DIPK1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by DIPK1A-low versus DIPK1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIPK1A→partner) and Y-score (partner→DIPK1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.256	-2.700	.011	.005	3	1
UCEC	eIF4E →	+0.224	+3.472	.008	.002	3	1
UCEC	A-Raf_pS299 →	-0.140	-3.321	.003	.010	3	1
UCEC	ERK2 →	+0.188	+2.000	.015	.030	3	1
UCEC	GAPDH →	+0.670	+3.584	.001	.002	3	1
UCEC	Heregulin →	-0.155	-1.906	.001	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

EGFR_pY1068 by DIPK1A expression — UCEC

Explore this box plot interactively →