DIP2C

Across TCGA cell cohorts, DIP2C mutation is significantly associated with the RNA expression of many other genes, with 2,273 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DIP2C-associated genes across cancer lineages are OTC, FOXE3, and ATL2. Each is linked with DIP2C in more than 2 cancer types. Because this analysis shows association rather than direction, both DIP2C-to-partner and partner-to-DIP2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTC grouped by DIP2C-low versus DIP2C-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIP2C→partner) and Y-score (partner→DIP2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OTC →	+0.052	+2.207	<.001	.008	3	3
LARGE_INTESTINE	FOXE3 →	+0.108	+2.804	<.001	<.001	3	2
BREAST	ATL2 →	+0.730	+3.220	.003	.005	3	2
BREAST	MGAT4C →	+0.234	+2.524	.006	.003	3	2
BREAST	FAM181B →	+0.408	+3.736	.005	<.001	3	2
BREAST	C9orf135 →	+0.237	+2.337	.009	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,273 associations by consensus.

OTC by DIP2C expression — BLOOD_Leukemia

Explore this box plot interactively →