DIP2C

Across TCGA cell cohorts, DIP2C mutation is significantly associated with the mutation status of many other genes, with 7,212 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DIP2C-associated genes across cancer lineages are COL16A1, LAMA2, and PCNX2. Each is linked with DIP2C in more than 6 cancer types. Because this analysis shows association rather than direction, both DIP2C-to-partner and partner-to-DIP2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL16A1 grouped by DIP2C-low versus DIP2C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIP2C→partner) and Y-score (partner→DIP2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COL16A1 →	+3.378	+2.510	<.001	<.001	1	7
BLOOD_Leukemia	LAMA2 →	+2.399	+2.918	<.001	<.001	1	7
BREAST	PCNX2 →	+3.378	+2.637	.004	.004	1	7
BLOOD_Lymphoma	GUCY1B1 →	+3.025	+3.754	.006	.006	1	6
SKIN	PTPRS →	+3.265	+2.643	.001	.001	1	6
LARGE_INTESTINE	PDE10A →	+2.700	+2.050	<.001	<.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,212 associations by consensus.

COL16A1 by DIP2C expression — LARGE_INTESTINE

Explore this box plot interactively →