DIP2B

Across TCGA patient cohorts, DIP2B mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIP2B-associated genes across cancer lineages are ATM, PKC-delta_pS664, and 4E-BP1. Each is linked with DIP2B in more than 2 cancer types. Because this analysis shows association rather than direction, both DIP2B-to-partner and partner-to-DIP2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DIP2B-low versus DIP2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIP2B→partner) and Y-score (partner→DIP2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.574	-3.308	<.001	<.001	3	3
UCEC	PKC-delta_pS664 →	-0.084	-2.321	.020	.005	3	3
UCEC	4E-BP1 →	+0.304	+3.906	<.001	<.001	3	3
COAD	Bcl-xL →	-0.223	-3.000	.031	.034	3	2
COAD	Caspase-7-cleavedD198 →	+1.224	+3.321	<.001	.009	3	2
COAD	cIAP →	+0.111	+2.519	.044	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

ATM by DIP2B expression — UCEC

Explore this box plot interactively →