DIP2A

Across TCGA patient cohorts, DIP2A mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIP2A-associated genes across cancer lineages are GAPDH, eIF4E, and p90 RSK. Each is linked with DIP2A in more than 2 cancer types. Because this analysis shows association rather than direction, both DIP2A-to-partner and partner-to-DIP2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by DIP2A-low versus DIP2A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIP2A→partner) and Y-score (partner→DIP2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GAPDH →	+0.605	+3.321	.009	.009	3	3
SKCM	eIF4E →	+0.140	+3.000	.047	.034	3	3
UCEC	p90 RSK →	+0.129	+1.363	.012	.008	3	3
UCEC	4E-BP1 →	+0.304	+2.736	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.333	+1.584	.028	.015	3	3
STAD	FoxM1 →	+0.455	+3.031	<.001	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

GAPDH by DIP2A expression — SKCM

Explore this box plot interactively →