Across TCGA patient cohorts, DIO3 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,180 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DIO3-associated proteins across cancer lineages are HSPA12A, TLN2, and PPP1R12B. Each is linked with DIO3 in more than 6 cancer types. Because this analysis shows association rather than direction, both DIO3-to-partner and partner-to-DIO3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DIO3→partner) and Y-score (partner→DIO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSPA12A →	+0.783	+0.561	<.001	<.001	3	7
LSCC	TLN2 →	+0.550	+0.429	<.001	<.001	3	7
UCEC	PPP1R12B →	+0.796	+0.391	<.001	<.001	3	6
UCEC	CAVIN1 →	+0.772	+0.427	<.001	<.001	3	6
UCEC	FERMT2 →	+0.569	+0.430	<.001	<.001	3	6
UCEC	SORBS3 →	+0.500	+0.381	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,180 associations by consensus.

Exploration

DIO3 survival (RNA) · tumor vs normal (RNA) · all DIO3 data types