Across TCGA patient cohorts, DIO3 mutation is significantly associated with the RNA expression of many other genes, with 4,464 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIO3-associated genes across cancer lineages are HMGN2P20, CHASERR, and H3C1. Each is linked with DIO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIO3-to-partner and partner-to-DIO3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIO3→partner) and Y-score (partner→DIO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HMGN2P20 →	+0.317	+2.650	.008	.002	3	2
UCEC	CHASERR →	+0.386	+1.880	.004	.004	3	2
UCEC	H3C1 →	+0.621	+1.458	<.001	.001	3	2
UCEC	CCL3 →	+0.561	+1.745	.002	.004	3	2
UCEC	COX15 →	+0.500	+1.632	<.001	<.001	3	2
UCEC	DUSP15 →	-0.519	-1.808	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,464 associations by consensus.

Exploration

DIO3 survival (RNA) · tumor vs normal (RNA) · all DIO3 data types