Across TCGA patient cohorts, DIO3 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIO3-associated genes across cancer lineages are EGFR_pY1068, Rad50, and TFRC. Each is linked with DIO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIO3-to-partner and partner-to-DIO3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIO3→partner) and Y-score (partner→DIO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.182	-2.087	.016	.004	3	2
UCEC	Rad50 →	-0.151	-1.321	.039	.012	3	2
UCEC	TFRC →	+0.399	+2.087	.012	.004	3	2
UCEC	ATM →	-0.436	-1.530	.001	.004	3	2
UCEC	4E-BP1 →	+0.342	+2.999	<.001	<.001	3	2
UCEC	C-Raf →	+0.167	+1.874	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration

DIO3 survival (RNA) · tumor vs normal (RNA) · all DIO3 data types