Across TCGA cell cohorts, DIO3 RNA expression is significantly associated with the go_rna of many other GO terms, with 636 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible DIO3-associated GO terms across cancer lineages are Fat cell proliferation, Negative regulation of myoblast fusion, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with DIO3 in more than 5 cancer types. Because this analysis shows association rather than direction, both DIO3-to-partner and partner-to-DIO3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DIO3→partner) and Y-score (partner→DIO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Fat cell proliferation →	-0.331	-0.971	<.001	.001	1	6
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.102	+0.174	.001	.008	3	4
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.100	+0.185	.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	Glucose homeostasis →	+0.061	+0.267	<.001	.003	3	4
LARGE_INTESTINE	Thyroid hormone catabolic process →	+0.681	+1.715	<.001	<.001	3	3
PANCREAS	Regulation of lamellipodium assembly →	+0.113	+0.966	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 636 associations by consensus.

Exploration

DIO3 survival (RNA) · tumor vs normal (RNA) · all DIO3 data types