Across TCGA patient cohorts, DIO2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIO2-associated genes across cancer lineages are ATM, PDCD4, and STAT3_pY705. Each is linked with DIO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DIO2-to-partner and partner-to-DIO2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIO2→partner) and Y-score (partner→DIO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.343	-2.102	.016	.016	3	3
UCEC	PDCD4 →	-0.380	-1.137	.010	.041	3	2
UCEC	STAT3_pY705 →	-0.327	-1.864	<.001	.002	3	2
UCEC	VHL →	-0.469	-1.247	.028	.041	3	2
SKCM	Bcl-2 →	-0.462	-2.321	.009	.035	2	3
UCEC	MEK1 →	+0.431	+3.169	<.001	<.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

DIO2 survival (RNA) · tumor vs normal (RNA) · all DIO2 data types