Across TCGA cell cohorts, DIO2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,128 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DIO2-associated GO terms across cancer lineages are Thyroid hormone catabolic process, Negative regulation of endodermal cell differentiation, and Schwann cell differentiation. Each is linked with DIO2 in more than 16 cancer types. Because this analysis shows association rather than direction, both DIO2-to-partner and partner-to-DIO2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DIO2→partner) and Y-score (partner→DIO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Thyroid hormone catabolic process →	+2.157	+4.441	<.001	<.001	3	17
OVARY	Negative regulation of endodermal cell differentiation →	+1.452	+1.905	<.001	.003	3	10
BONE	Schwann cell differentiation →	+0.173	+1.819	<.001	.003	3	9
BONE	Protein localization to vacuole →	+0.085	+1.856	<.001	.003	3	9
BREAST	Regulation of protein modification by small protein conjugation or removal →	+0.048	+1.880	.004	.005	3	9
OESOPHAGUS	Regulation of intracellular transport →	+0.078	+3.530	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,128 associations by consensus.

Exploration

DIO2 survival (RNA) · tumor vs normal (RNA) · all DIO2 data types