Across TCGA cell cohorts, DIO2 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DIO2-associated genes across cancer lineages are GPHB5 and C1orf185. Each is linked with DIO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIO2-to-partner and partner-to-DIO2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIO2→partner) and Y-score (partner→DIO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPHB5 →	+0.070	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	C1orf185 →	+0.053	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Exploration

DIO2 survival (RNA) · tumor vs normal (RNA) · all DIO2 data types