Across TCGA pan-cancer cohorts, DIO1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated DIO1 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DIO1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DIO1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC and GBM are the cancer types where DIO1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.927	0.592	.001	97	view →
GBM	OS	Tertile	All	0.868	0.671	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: DIO1 tumor-vs-normal RNA expression · all DIO1 data types