Across TCGA patient cohorts, DIO1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,652 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible DIO1-associated proteins across cancer lineages are UBA7, PRKAR1A_S83, and RPF1. Each is linked with DIO1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DIO1-to-partner and partner-to-DIO1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DIO1→partner) and Y-score (partner→DIO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	UBA7 →	+0.363	+0.270	<.001	<.001	3	4
PDAC	PRKAR1A_S83 →	+0.565	+0.327	<.001	<.001	3	3
BRCA	RPF1 →	-0.472	-1.637	<.001	.001	3	3
BRCA	RPL4 →	-0.342	-1.788	<.001	<.001	3	3
HNSC	RPS2 →	-0.209	-0.475	.001	.005	3	3
BRCA	RPS23 →	-0.248	-1.401	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,652 associations by consensus.

Exploration

DIO1 survival (RNA) · tumor vs normal (RNA) · all DIO1 data types