Across TCGA patient cohorts, DIO1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIO1-associated genes across cancer lineages are 4E-BP1, A-Raf_pS299, and Ku80. Each is linked with DIO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIO1-to-partner and partner-to-DIO1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIO1→partner) and Y-score (partner→DIO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.404	+3.029	.002	.018	3	2
UCEC	A-Raf_pS299 →	-0.151	-2.321	.011	.035	3	1
UCEC	Ku80 →	+0.344	+3.013	.003	.018	3	1
UCEC	Notch1 →	+0.230	+2.321	.001	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.489	-2.308	.030	.036	3	1
UCEC	p70-S6K_pT389 →	-0.244	-2.321	.010	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

DIO1 survival (RNA) · tumor vs normal (RNA) · all DIO1 data types