Across TCGA cell cohorts, DIO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,421 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible DIO1-associated GO terms across cancer lineages are Negative regulation of cilium assembly, Endosomal transport, and Regulation of organelle assembly. Each is linked with DIO1 in more than 7 cancer types. Because this analysis shows association rather than direction, both DIO1-to-partner and partner-to-DIO1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DIO1→partner) and Y-score (partner→DIO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of cilium assembly →	+0.044	+0.118	<.001	<.001	3	8
SKIN	Endosomal transport →	+0.047	+0.064	<.001	.005	2	8
BLOOD_Lymphoma	Regulation of organelle assembly →	+0.039	+0.155	<.001	<.001	3	7
BLOOD_Lymphoma	Negative regulation of macroautophagy →	+0.044	+0.145	<.001	.001	2	8
BLOOD_Lymphoma	Endocytic recycling →	+0.056	+0.181	<.001	<.001	3	7
BLOOD_Lymphoma	Vesicle-mediated transport to the plasma membrane →	+0.038	+0.129	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,421 associations by consensus.

Exploration

DIO1 survival (RNA) · tumor vs normal (RNA) · all DIO1 data types