DIDO1

Across TCGA patient cohorts, DIDO1 mutation is significantly associated with the total protein of many other genes, with 102 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIDO1-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and PCNA. Each is linked with DIDO1 in more than 7 cancer types. Because this analysis shows association rather than direction, both DIDO1-to-partner and partner-to-DIDO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DIDO1-low versus DIDO1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIDO1→partner) and Y-score (partner→DIDO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.775	+2.745	<.001	<.001	3	8
STAD	eEF2 →	+0.294	+1.700	.011	.042	3	7
COAD	PCNA →	+0.270	+1.856	<.001	.004	3	6
STAD	TFRC →	+0.656	+3.999	.005	<.001	2	6
COAD	ASNS →	+0.532	+1.511	<.001	.018	3	5
COAD	Chk1 →	+0.313	+2.700	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

Caspase-7-cleavedD198 by DIDO1 expression — COAD

Explore this box plot interactively →