DIDO1

Across TCGA cell cohorts, DIDO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,964 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DIDO1-associated GO terms across cancer lineages are Regulatory ncRNA-mediated gene silencing, Regulation of sister chromatid cohesion, and Regulation of double-strand break repair. Each is linked with DIDO1 in more than 16 cancer types. Because this analysis shows association rather than direction, both DIDO1-to-partner and partner-to-DIDO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulatory ncRNA-mediated gene silencing grouped by DIDO1-low versus DIDO1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DIDO1→partner) and Y-score (partner→DIDO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulatory ncRNA-mediated gene silencing →	+0.080	+0.936	.003	.003	3	17
BONE	Regulation of sister chromatid cohesion →	+0.175	+1.212	<.001	<.001	3	16
SOFT_TISSUE	Regulation of double-strand break repair →	+0.062	+0.706	<.001	<.001	3	15
OVARY	RNA export from nucleus →	+0.112	+0.972	<.001	<.001	3	15
KIDNEY	Promoter clearance during DNA-templated transcription →	+0.148	+0.865	<.001	.001	3	15
KIDNEY	RNA polymerase II promoter clearance →	+0.148	+0.865	<.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,964 associations by consensus.

Regulatory ncRNA-mediated gene silencing by DIDO1 expression — BONE

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