DICER1

Across TCGA pan-cancer cohorts, DICER1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DICER1 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DICER1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DICER1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, COAD, and PDAC are the cancer types where DICER1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.933	0.541	<.001	31	view →
COAD	DFS	Median	II,III,IV	0.877	1.000	.016	24	view →
PDAC	DFS	Median	All	0.590	0.849	.010	21	view →
GBM	OS	Quartile	All	0.253	0.469	.008	20	view →
UCEC	OS	Quartile	All	1.000	0.833	.018	8	view →
HNSC	DFS	Median	II,III,IV	0.992	0.907	.016	3	view →
LUAD	OS	Quartile	II,III,IV	0.291	0.848	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DICER1–LSCC (OS)

Open the LSCC breakdown →