DICER1

Across TCGA patient cohorts, DICER1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,577 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible DICER1-associated proteins across cancer lineages are CDC42BPB, UBR7, and PPP4R3A. Each is linked with DICER1 in more than 6 cancer types. Because this analysis shows association rather than direction, both DICER1-to-partner and partner-to-DICER1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DICER1 versus CDC42BPB in GBM, with a Pearson correlation of 0.50.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DICER1→partner) and Y-score (partner→DICER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CDC42BPB →	+0.268	+0.496	<.001	<.001	3	7
LSCC	UBR7 →	+0.347	+0.391	<.001	<.001	3	6
LSCC	PPP4R3A →	+0.262	+0.368	<.001	<.001	3	6
LSCC	ATXN3 →	+0.273	+0.483	<.001	<.001	3	6
BRCA	BAG5 →	+0.261	+0.634	<.001	.002	3	6
LSCC	HSP90AA1 →	+0.261	+0.355	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,577 associations by consensus.

DICER1 vs CDC42BPB — GBM

Explore this scatter interactively →