DICER1

Across TCGA patient cohorts, DICER1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,309 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DICER1-associated genes across cancer lineages are CBX7, DLGAP5, and CCNA2. Each is linked with DICER1 in more than 6 cancer types. Because this analysis shows association rather than direction, both DICER1-to-partner and partner-to-DICER1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DICER1 versus CBX7 in GBM, with a Pearson correlation of -0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DICER1→partner) and Y-score (partner→DICER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CBX7 →	-0.567	-0.282	<.001	<.001	3	7
LUAD	DLGAP5 →	+1.209	+0.204	<.001	<.001	3	6
LUAD	CCNA2 →	+0.907	+0.186	<.001	<.001	3	6
UCEC	ERO1A →	+0.843	+0.305	<.001	<.001	3	6
BRCA	CAB39L →	-0.765	-0.230	.006	.003	3	6
LUAD	CDKN3 →	+0.971	+0.192	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,309 associations by consensus.

DICER1 vs CBX7 — GBM

Explore this scatter interactively →