DICER1

Across TCGA patient cohorts, DICER1 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DICER1-associated genes across cancer lineages are eEF2, ATM, and Cyclin-E2. Each is linked with DICER1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DICER1-to-partner and partner-to-DICER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by DICER1-low versus DICER1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DICER1→partner) and Y-score (partner→DICER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.201	+1.459	.016	.009	3	3
UCEC	ATM →	-0.390	-1.289	<.001	<.001	3	3
UCEC	Cyclin-E2 →	+0.095	+1.009	.015	.015	3	3
LUSC	Cyclin-E1 →	-0.376	-2.990	.010	.036	3	2
UCEC	JNK_pT183_Y185 →	-0.103	-0.906	.009	.035	3	2
UCEC	MEK1 →	+0.242	+1.178	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

eEF2 by DICER1 expression — UCEC

Explore this box plot interactively →