DICER1

Across TCGA cell cohorts, DICER1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,733 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DICER1-associated GO terms across cancer lineages are Regulation of Schwann cell differentiation, Epigenetic regulation of gene expression, and DNA-templated DNA replication maintenance of fidelity. Each is linked with DICER1 in more than 17 cancer types. Because this analysis shows association rather than direction, both DICER1-to-partner and partner-to-DICER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of Schwann cell differentiation grouped by DICER1-low versus DICER1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DICER1→partner) and Y-score (partner→DICER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of Schwann cell differentiation →	+0.221	+1.000	<.001	<.001	3	18
SOFT_TISSUE	Epigenetic regulation of gene expression →	+0.073	+1.514	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication maintenance of fidelity →	+0.094	+1.049	<.001	.002	3	18
OESOPHAGUS	Positive regulation of mRNA metabolic process →	+0.076	+1.137	.003	.004	3	17
BLOOD_Myeloma	Replication fork processing →	+0.092	+0.983	.009	.009	3	17
BLOOD_Lymphoma	Positive regulation of mRNA catabolic process →	+0.056	+0.932	<.001	.008	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,733 associations by consensus.

Regulation of Schwann cell differentiation by DICER1 expression — OESOPHAGUS

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