DIAPH3

Across TCGA pan-cancer cohorts, DIAPH3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DIAPH3 data layer compared with 31 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DIAPH3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DIAPH3 expression acts as an unfavorable survival marker.

LUAD, GBM, and HNSC are the cancer types where DIAPH3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.524	0.927	.014	6	view →
GBM	DFS	Quartile	All	0.266	0.553	.034	4	view →
HNSC	DFS	Median	III,IV	0.700	0.888	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DIAPH3–LUAD (OS)

Open the LUAD breakdown →