DIAPH3

Across TCGA patient cohorts, DIAPH3 mutation is significantly associated with the RNA expression of many other genes, with 3,861 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIAPH3-associated genes across cancer lineages are PARP2, MRPL20, and ENO1. Each is linked with DIAPH3 in more than 3 cancer types. Because this analysis shows association rather than direction, both DIAPH3-to-partner and partner-to-DIAPH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PARP2 grouped by DIAPH3-low versus DIAPH3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIAPH3→partner) and Y-score (partner→DIAPH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PARP2 →	+0.422	+2.039	<.001	<.001	3	4
UCEC	MRPL20 →	+0.284	+2.021	.002	.005	3	4
SKCM	ENO1 →	+0.547	+2.964	.003	<.001	3	3
UCEC	SYT7 →	-0.827	-1.939	<.001	<.001	3	3
UCEC	PARK7 →	+0.260	+1.606	.001	.005	3	3
UCEC	MRPS15 →	+0.392	+1.691	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,861 associations by consensus.

PARP2 by DIAPH3 expression — UCEC

Explore this box plot interactively →