DIAPH3

Across TCGA patient cohorts, DIAPH3 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIAPH3-associated genes across cancer lineages are PCNA, TFRC, and HER2. Each is linked with DIAPH3 in more than 3 cancer types. Because this analysis shows association rather than direction, both DIAPH3-to-partner and partner-to-DIAPH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by DIAPH3-low versus DIAPH3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIAPH3→partner) and Y-score (partner→DIAPH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.271	+2.044	<.001	<.001	3	4
UCEC	TFRC →	+0.446	+1.847	.002	.007	3	3
LUSC	HER2 →	+0.405	+2.816	.047	.036	2	3
SKCM	eEF2 →	+0.426	+3.169	.017	.019	3	2
UCEC	JNK_pT183_Y185 →	-0.160	-2.000	<.001	<.001	3	2
UCEC	NF-kB-p65_pS536 →	-0.389	-2.502	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

PCNA by DIAPH3 expression — UCEC

Explore this box plot interactively →