DIAPH3

Across TCGA cell cohorts, DIAPH3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,513 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DIAPH3-associated GO terms across cancer lineages are Regulation of nuclear division, Regulation of mitotic nuclear division, and Positive regulation of chromosome condensation. Each is linked with DIAPH3 in more than 19 cancer types. Because this analysis shows association rather than direction, both DIAPH3-to-partner and partner-to-DIAPH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nuclear division grouped by DIAPH3-low versus DIAPH3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DIAPH3→partner) and Y-score (partner→DIAPH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of nuclear division →	+0.153	+1.811	.006	<.001	3	20
OESOPHAGUS	Regulation of mitotic nuclear division →	+0.144	+1.891	.008	.003	3	20
BLOOD_Myeloma	Positive regulation of chromosome condensation →	+0.215	+1.428	<.001	<.001	3	20
BLOOD_Myeloma	Regulation of metaphase/anaphase transition of cell cycle →	+0.091	+1.026	.007	.006	3	20
OESOPHAGUS	Nuclear division →	+0.099	+1.895	.009	.002	3	20
BLOOD_Lymphoma	Attachment of mitotic spindle microtubules to kinetochore →	+0.144	+1.057	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,513 associations by consensus.

Regulation of nuclear division by DIAPH3 expression — BONE

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