DIAPH3

Across TCGA cell cohorts, DIAPH3 mutation is significantly associated with the RNA expression of many other genes, with 105 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DIAPH3-associated genes across cancer lineages are ODF1, SERPINA7, and C1orf158. Each is linked with DIAPH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIAPH3-to-partner and partner-to-DIAPH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ODF1 grouped by DIAPH3-low versus DIAPH3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIAPH3→partner) and Y-score (partner→DIAPH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ODF1 →	+0.066	+3.529	<.001	<.001	3	2
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1
CNS	MYF5 →	+0.749	+5.321	<.001	.005	3	1
CNS	PRAMEF26 →	+0.270	+5.754	.005	.002	3	1
OVARY	S100A7A →	+1.007	+4.029	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 105 associations by consensus.

ODF1 by DIAPH3 expression — BLOOD_Leukemia

Explore this box plot interactively →