Across TCGA pan-cancer cohorts, DIAPH3-AS2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of DIAPH3-AS2’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where DIAPH3-AS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DIAPH3-AS2 is over-expressed in tumor.
BRCA, ESCA, and STAD are the cancer types where DIAPH3-AS2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DIAPH3-AS2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.