DIAPH2

Across TCGA patient cohorts, DIAPH2 mutation is significantly associated with the RNA expression of many other genes, with 4,929 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIAPH2-associated genes across cancer lineages are TXNRD1, PSMC3IP, and RNU1-153P. Each is linked with DIAPH2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DIAPH2-to-partner and partner-to-DIAPH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNRD1 grouped by DIAPH2-low versus DIAPH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIAPH2→partner) and Y-score (partner→DIAPH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TXNRD1 →	+0.439	+1.306	.005	<.001	3	4
UCEC	PSMC3IP →	+0.535	+1.560	<.001	<.001	3	4
UCEC	RNU1-153P →	-0.465	-1.643	.002	.002	3	3
UCEC	IBA57 →	+0.271	+1.659	.001	.001	3	3
UCEC	SKA2 →	+0.463	+1.560	<.001	<.001	3	3
UCEC	FAM162B →	-0.488	-1.350	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,929 associations by consensus.

TXNRD1 by DIAPH2 expression — UCEC

Explore this box plot interactively →