DIAPH2

Across TCGA patient cohorts, DIAPH2 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIAPH2-associated genes across cancer lineages are ASNS, 4E-BP1, and STAT5a. Each is linked with DIAPH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DIAPH2-to-partner and partner-to-DIAPH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by DIAPH2-low versus DIAPH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIAPH2→partner) and Y-score (partner→DIAPH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.351	+1.321	<.001	.010	3	3
UCEC	4E-BP1 →	+0.256	+2.169	<.001	.002	3	3
LUSC	STAT5a →	+0.632	+3.179	.016	.010	3	2
BLCA	PTEN →	-0.386	-2.321	.018	.035	3	2
BLCA	VEGFR2 →	-0.529	-2.321	<.001	.035	3	2
LUAD	PKC-a_pS657 →	-0.402	-3.296	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

ASNS by DIAPH2 expression — UCEC

Explore this box plot interactively →