DIAPH2

Across TCGA cell cohorts, DIAPH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,290 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DIAPH2-associated GO terms across cancer lineages are Negative regulation of maintenance of sister chromatid cohesion, Negative regulation of maintenance of mitotic sister chromatid cohesion, and Positive regulation of vascular permeability. Each is linked with DIAPH2 in more than 7 cancer types. Because this analysis shows association rather than direction, both DIAPH2-to-partner and partner-to-DIAPH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of maintenance of sister chromatid cohesion grouped by DIAPH2-low versus DIAPH2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DIAPH2→partner) and Y-score (partner→DIAPH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of maintenance of sister chromatid cohesion →	+0.170	+1.449	<.001	.001	3	8
BONE	Negative regulation of maintenance of mitotic sister chromatid cohesion →	+0.170	+1.449	<.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Positive regulation of vascular permeability →	-0.150	-0.872	.001	.004	3	6
BREAST	Negative regulation of stress-activated MAPK cascade →	+0.145	+0.911	.001	.002	3	6
BLOOD_Lymphoma	Negative regulation of calcium ion transmembrane transporter activity →	+0.096	+0.754	<.001	.004	3	5
BLOOD_Lymphoma	Regulation of mesonephros development →	-0.852	-0.752	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,290 associations by consensus.

Negative regulation of maintenance of sister chromatid cohesion by DIAPH2 expression — BONE

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