DIAPH2

Across TCGA cell cohorts, DIAPH2 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DIAPH2-associated genes across cancer lineages are MMP20, SPATA31A6, and KRTAP10-1. Each is linked with DIAPH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIAPH2-to-partner and partner-to-DIAPH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP20 grouped by DIAPH2-low versus DIAPH2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIAPH2→partner) and Y-score (partner→DIAPH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MMP20 →	+0.186	+4.222	.002	.007	3	1
SOFT_TISSUE	SPATA31A6 →	+0.014	+5.169	<.001	<.001	3	1
SOFT_TISSUE	KRTAP10-1 →	+0.043	+4.369	<.001	.008	3	1
SKIN	BHLHE23 →	+0.021	+3.700	<.001	.009	3	1
SKIN	MMP26 →	+0.011	+3.700	<.001	.009	3	1
SKIN	APOBEC4 →	+0.045	+3.491	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

MMP20 by DIAPH2 expression — SOFT_TISSUE

Explore this box plot interactively →