DHX58

Across TCGA pan-cancer cohorts, DHX58 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DHX58 data layer compared with 29 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DHX58 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DHX58 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where DHX58 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	1.000	0.623	.040	6	view →
CCRCC	OS	Median	IV	0.167	0.784	.038	6	view →
PDAC	DFS	Median	All	0.750	0.791	.025	2	view →
GBM	DFS	Median	All	0.285	0.431	.046	2	view →
LUAD	OS	Quartile	All	0.493	0.879	.023	1	view →
LSCC	DFS	Median	II,III,IV	1.000	0.571	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DHX58–HNSC (DFS)

Open the HNSC breakdown →