DHX58

Across TCGA patient cohorts, DHX58 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHX58-associated genes across cancer lineages are mTOR_pS2448, GSK-3_pS9, and INPP4B. Each is linked with DHX58 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHX58-to-partner and partner-to-DHX58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by DHX58-low versus DHX58-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX58→partner) and Y-score (partner→DHX58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.136	-2.439	.027	.019	3	2
UCEC	GSK-3_pS9 →	-0.448	-3.321	.007	.009	3	1
UCEC	INPP4B →	-0.314	-2.321	.018	.034	3	1
UCEC	MEK1 →	+0.399	+2.321	.008	.006	3	1
UCEC	MSH2 →	-0.308	-3.295	.001	.009	3	1
UCEC	Notch1 →	+0.160	+2.321	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

mTOR_pS2448 by DHX58 expression — UCEC

Explore this box plot interactively →