DHX58

Across TCGA cell cohorts, DHX58 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DHX58-associated genes across cancer lineages are OR5AU1, PHOX2B, and MUC5B. Each is linked with DHX58 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHX58-to-partner and partner-to-DHX58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5AU1 grouped by DHX58-low versus DHX58-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX58→partner) and Y-score (partner→DHX58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR5AU1 →	+0.019	+4.734	.007	.002	3	1
BLOOD_Leukemia	PHOX2B →	+0.017	+3.365	<.001	.005	3	1
BLOOD_Leukemia	MUC5B →	+0.314	+3.474	<.001	.007	3	1
BLOOD_Leukemia	BHLHE23 →	+0.901	+3.409	.008	.008	3	1
BLOOD_Leukemia	NPFFR1 →	+0.008	+3.359	.008	.002	3	1
BLOOD_Leukemia	CLDN8 →	+0.009	+3.556	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

OR5AU1 by DHX58 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →