DHX57

Across TCGA patient cohorts, DHX57 mutation is significantly associated with the RNA expression of many other genes, with 4,731 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHX57-associated genes across cancer lineages are ATF4, UHRF1, and ERLIN1. Each is linked with DHX57 in more than 3 cancer types. Because this analysis shows association rather than direction, both DHX57-to-partner and partner-to-DHX57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATF4 grouped by DHX57-low versus DHX57-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX57→partner) and Y-score (partner→DHX57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ATF4 →	+0.501	+3.357	.001	.005	3	4
UCEC	UHRF1 →	+0.781	+2.046	<.001	<.001	3	3
SKCM	ERLIN1 →	+0.519	+2.616	.002	<.001	3	3
LUAD	GLRXP1 →	+0.100	+2.893	<.001	.005	3	3
SKCM	RPL23AP82 →	+0.536	+2.935	<.001	<.001	3	3
COAD	GAS2L1 →	+0.854	+3.500	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,731 associations by consensus.

ATF4 by DHX57 expression — LUAD

Explore this box plot interactively →