DHX57

Across TCGA patient cohorts, DHX57 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHX57-associated genes across cancer lineages are MEK1, PDCD4, and Shc_pY317. Each is linked with DHX57 in more than 2 cancer types. Because this analysis shows association rather than direction, both DHX57-to-partner and partner-to-DHX57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by DHX57-low versus DHX57-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX57→partner) and Y-score (partner→DHX57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.319	+1.716	.002	.003	3	3
UCEC	PDCD4 →	-0.370	-1.054	.005	.029	3	3
COAD	Shc_pY317 →	-0.228	-3.153	.001	.018	3	3
UCEC	4E-BP1 →	+0.309	+4.247	<.001	<.001	3	3
COAD	14-3-3_beta →	-0.211	-3.153	.013	.018	3	2
UCEC	EGFR_pY1068 →	-0.202	-1.847	.004	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

MEK1 by DHX57 expression — UCEC

Explore this box plot interactively →