DHX57

Across TCGA cell cohorts, DHX57 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,411 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible DHX57-associated GO terms across cancer lineages are RNA localization, Negative regulation of chromosome organization, and Heterochromatin formation. Each is linked with DHX57 in more than 17 cancer types. Because this analysis shows association rather than direction, both DHX57-to-partner and partner-to-DHX57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA localization grouped by DHX57-low versus DHX57-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX57→partner) and Y-score (partner→DHX57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RNA localization →	+0.122	+0.645	.001	.004	3	18
LARGE_INTESTINE	Negative regulation of chromosome organization →	+0.087	+0.815	<.001	<.001	3	17
PANCREAS	Heterochromatin formation →	+0.071	+0.937	<.001	<.001	3	17
SOFT_TISSUE	Nucleic acid transport →	+0.107	+0.937	<.001	<.001	3	17
SOFT_TISSUE	RNA transport →	+0.107	+0.937	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Establishment of RNA localization →	+0.104	+1.111	.002	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,411 associations by consensus.

RNA localization by DHX57 expression — BONE

Explore this box plot interactively →