DHX57

Across TCGA cell cohorts, DHX57 mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DHX57-associated genes across cancer lineages are BMP15, MPC1L, and BTNL2. Each is linked with DHX57 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHX57-to-partner and partner-to-DHX57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BMP15 grouped by DHX57-low versus DHX57-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX57→partner) and Y-score (partner→DHX57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BMP15 →	+0.032	+5.029	<.001	.006	3	2
LUNG_SCLC	MPC1L →	+0.075	+5.029	<.001	.006	3	2
LUNG_NSCLC_LUAD	BTNL2 →	+0.062	+3.760	.005	.008	3	2
CNS	IDI2 →	+1.180	+3.874	<.001	.006	3	2
BLOOD_Leukemia	FIGLA →	+0.022	+4.984	<.001	.002	3	2
BLOOD_Lymphoma	FCN3 →	+0.025	+2.691	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

BMP15 by DHX57 expression — LUNG_SCLC

Explore this box plot interactively →