DHX40

Across TCGA pan-cancer cohorts, DHX40 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DHX40 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DHX40 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DHX40 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, PDAC, and LSCC are the cancer types where DHX40 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	II,III,IV	1.000	0.322	<.001	48	view →
PDAC	OS	Quartile	II,III,IV	0.295	0.601	.002	37	view →
LSCC	OS	Quartile	II,III,IV	0.933	0.536	.018	23	view →
CCRCC	DFS	Median	III,IV	0.105	0.904	.008	15	view →
HNSC	DFS	Median	II,III,IV	0.885	0.681	.003	13	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DHX40–LUAD (OS)

Open the LUAD breakdown →