DHX38

Across TCGA pan-cancer cohorts, DHX38 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DHX38 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher DHX38 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DHX38 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

GBM, COAD, and LSCC are the cancer types where DHX38 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.491	0.270	.019	9	view →
COAD	DFS	Median	IV	0.565	1.000	.028	6	view →
LSCC	OS	Median	All	0.812	0.920	.024	5	view →
HNSC	DFS	Median	III,IV	0.718	0.864	.028	4	view →
CCRCC	OS	Median	IV	1.000	0.202	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DHX38–GBM (DFS)

Open the GBM breakdown →