DHX38

Across TCGA patient cohorts, DHX38 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHX38-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and INPP4B. Each is linked with DHX38 in more than 2 cancer types. Because this analysis shows association rather than direction, both DHX38-to-partner and partner-to-DHX38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DHX38-low versus DHX38-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX38→partner) and Y-score (partner→DHX38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.718	+2.756	<.001	<.001	3	3
UCEC	eIF4E →	+0.209	+1.947	.001	<.001	3	2
UCEC	INPP4B →	-0.219	-2.169	.027	.002	3	2
UCEC	PCNA →	+0.156	+1.362	.018	.034	3	2
UCEC	STAT5a →	+0.252	+1.473	.039	.006	3	2
UCEC	Tuberin_pT1462 →	+0.198	+1.232	.005	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Caspase-7-cleavedD198 by DHX38 expression — UCEC

Explore this box plot interactively →