DHX38

Across TCGA cell cohorts, DHX38 mutation is significantly associated with the RNA expression of many other genes, with 413 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DHX38-associated genes across cancer lineages are TEX43, HSCB, and ELP2. Each is linked with DHX38 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHX38-to-partner and partner-to-DHX38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX43 grouped by DHX38-low versus DHX38-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX38→partner) and Y-score (partner→DHX38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TEX43 →	+0.166	+3.353	<.001	.001	3	2
LARGE_INTESTINE	HSCB →	+0.579	+3.169	.002	.009	3	2
LARGE_INTESTINE	ELP2 →	+0.682	+3.169	.001	.006	3	2
LARGE_INTESTINE	MT-CO3 →	-0.849	-3.416	<.001	.002	3	2
LARGE_INTESTINE	MT-ATP8 →	-0.944	-3.416	<.001	.002	3	2
SOFT_TISSUE	ZNF705G →	+0.172	+3.295	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 413 associations by consensus.

TEX43 by DHX38 expression — LUNG_SCLC

Explore this box plot interactively →