DHX36

Across TCGA pan-cancer cohorts, DHX36 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DHX36 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DHX36 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DHX36 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where DHX36 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	0.123	0.785	.009	21	view →
LUAD	DFS	Tertile	II,III,IV	0.687	0.238	.011	18	view →
PDAC	OS	Quartile	III,IV	0.184	0.619	.001	12	view →
HNSC	DFS	Tertile	III,IV	0.476	1.000	.022	11	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DHX36–CCRCC (OS)

Open the CCRCC breakdown →